Algorithm description
AACDS classifies genomic variants in to 8 categories. Category 1 contains documented disease-causing nsSNP. Categories 2A and 3A represent nsSNPs in genes that have known associations with diseases (2A) or traits (3A), and these are sub-divided into categories 2B and 3B if they are also predicted to be deleterious by three or more programs. Category 4 comprises nsSNPs that are predicted to be damaging but lie in genes that have no clinical associations. Conversely, Category 5 nsSNPs are located in genes that have disease or trait associations, but variants are predicted to be neutral. Category 6 represents neutral nsSNPs, whose genes have no clinical relations.